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Neuroscience

Director
Guy Drolet
Deputy director
Luc Vallières
Address
2705, boulevard Laurier, RC-9800
Québec (Québec)
CANADA G1V 4G2
Phone
+1 418-654-2152
Fax
+1 418-654-2753
Email
neurosciences@crchuq.ulaval.ca

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All active clinical studies

The neuroscience group is organized into multidisciplinary teams that study the biological mechanisms underpinning the normal and pathological functioning of the central and peripheral nervous system and the muscular system. Researchers in this field seek to advance our understanding of physiopathology and develop new treatments for deficiencies and disabilities caused by lesions or neurological, psychiatric, and neuromuscular diseases. Research themes concern neurodegenerative, neuromuscular, and neurogenetic diseases, cerebral and spinal lesions and trauma, the regeneration and reorganization of the nervous system, mental health, ophthalmology, the development of biotherapy and standardized clinical evaluation methods, and neuromodulation treatments. Researchers are very active in Université Laval’s Regroupement Neurosciences et Santé mentale (Neurosciences and Mental Health Group).

Active research projects (see all research project in this area)

The amyloid and beyond; A molecular answer to forget me not. IRSC
Georges Lévesque
Ribozyme as a new therapeutic molecule. Alzheimer Société du Canada
Georges Lévesque
Neurobiologie de la résilience et de la vulnérabilité au stress chronique: Implication des endorphines
Guy Drolet
Effets de la condition musculaire maternelle sur l'anthropométrie néonatale
Jean-François Bilodeau, Emmanuel Bujold, Jérôme Frenette, Isabelle Marc
Contribution of serotonergic reticulospinal pathways to locomotion after spinal cord injury
Frédéric Bretzner
The role of apoE in mild traumatic brain injury (CIHR)
Emmanuel Planel
Anesthesia and Alzheimer's disease pathogenesis (applied for CIHR)
Emmanuel Planel
Real time imaging of brain immune responses in mouse models of tauopathies (Alzheimer Society of Canada)
Jasna Kriz, Emmanuel Planel
Molecular and Biological Characterisation of Novel Genetic Markers Associated to the Common of Alzheimer's Disease in a Population Isolate from Eastern Canada (CIHR)
Georges Lévesque, Emmanuel Planel
Impact of diabetes on tau pathogenesis in vivo (CIHR)
Emmanuel Planel

Recent publications (see all publications in this area)

Sharma A, Patil AJ, Mansoor S, Estrago-Franco MF, Raymond V, Kenney MC, Kuppermann BD. Effects of dexamethasone on human trabecular meshwork cells in vitro. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,  2013. Epub
Lampron A, Elali A, Rivest S. Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment. Neuron,  2013. 78: 214-32
Perez CJ, Dumas A, Vallieres L, Guenet JL, Benavides F. Several Classical Mouse Inbred Strains, Including DBA/2, NOD/Lt, FVB/N, and SJL/J, Carry a Putative Loss-of-Function Allele of Gpr84. The Journal of heredity,  2013. Epub
Gulemetova R, Drolet G, Kinkead R. Neonatal stress augments the hypoxic chemoreflex of adult male rats by increasing AMPA-receptor mediated modulation. Experimental physiology,  2013. Epub
Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD. Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. The Journal of clinical investigation,  2013. Epub
Burel D, Li JH, Do-Rego JL, Wang AF, Luu-The V, Pelletier G, Tillet Y, Taragnat C, Kwon HB, Seong JY, Vaudry H. Gonadotropin-Releasing Hormone Stimulates the Biosynthesis of Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate in the Hypothalamus. Endocrinology,  2013. Epub
Whittington RA, Bretteville A, Dickler MF, Planel E. Anesthesia and tau pathology. Progress in neuro-psychopharmacology & biological psychiatry,  2013. Epub
Dufresne S, Frenette J. Investigation of wild-type and mycolactone-negative mutant M. ulcerans on skeletal muscle : IGF-1 protects against mycolactone-induced muscle catabolism. American journal of physiology. Regulatory, integrative and comparative physiology ,  2013. Epub
Elali A, Rivest S. The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease. Frontiers in physiology,  2013. 4: 45
Montoni A, Robu M, Pouliot E, Shah GM. Resistance to PARP-Inhibitors in Cancer Therapy. Frontiers in pharmacology,  2013. 4: 18
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